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Impact of Autophagy Process Induced by Cigarette Smoke on Follicle Development
Wu Chunli1,2, Wang Xuemei1, Yu Yi1, Gao Ying1, Ma Qianyun1, Xu Ying1*
1Medical College of Jiaxing University, Jiaxing 314001, China;
2Medical College of Ningbo University, Ningbo 315211, China
2Medical College of Ningbo University, Ningbo 315211, China
Abstract: Cigarette smoking (CS) is harmful life style. Approximately 250 million women worldwide are daily smokers. Regrettably， most women remain unaware of the adverse effects of cigarette smoking on fertility and ovarian function. Cigarette smoke exposure can decrease the number of primordial and growth follicle， deplete ovarian follicle reserve， impair ovarian function， descend female fertility and advance menopause. Cigarette smoke exposure can induce autophagy. Instead with autophagy is a key reason of follicle loss induced by cigarette smoke. Autophagy is considered as a potential therapeutic target for CS-related premature ovarian failure.
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