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Amyotrophic Lateral Sclerosis Associated FUS Protein and Stress Granule
Wei Yanming*, Luan Zhihua, Chen Xiuhong, Liang Rui
Experimental Centre, Shanxi University of Traditional Chinese Medicine, Jinzhong 030619, China
Abstract: Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder characterized by loss of motor neurons. As a RNA binding protein， fused in sarcoma (FUS) mutations cause ALS. Stress granules (SG) are cytosolic structures formed normally in response to induced stressors. FUS assembles into SG， while SG marker proteins are constituents of pathological FUS aggregates， implying that mutant FUS could disturb the function of SG and FUS aggregates might arise from SG. This review will discuss the mechanisms and regulation that FUS recruit into SG， analyze the relationship between SG and FUS aggregates， and provide implications for the roles of SG in FUS mutants caused ALS.
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