Planarian， A Good Screening Model In Vivo for Drugs Related to Regeneration and Aging

Abstract: Planarian has remarkable abilities of regeneration and belongs to Platyhelminthes. Its regeneration ability is due to the pluripotent adult stem cells almost all over its body and make it a good model animal for the study of stem cell differentiation， development， proliferation and regulation. Because the behavior of planarian stem cells can be studied in vivo， it has incomparable advantage compared with the stem cell research in vitro. Due to this unique biological feature and advantage， planarian can be used as a mass drug screening platform to screen drugs related to regeneration， aging and tumor. This article will review on the mechanism and regulation of planarian regeneration and lay the foundation to promote planarian to become a drug screening model in vivo.

CSTR: 32200.14.cjcb.2016.06.0013