Home > Browse Issues > Vol.38 No.6
Structure and Application of Human Equilibrative Nucleoside Transporter―A Review
Hao Zhenyu1, Liu Ruihua2, Wang Yingying1*, Mark Bartlam2
1Tianjin Key Laboratory of Environmental Remediation and Pollution Control, Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering,Nankai University, Tianjin 300071, China;
2College of Life Sciences, Nankai University, Tiajin 300071, China
2College of Life Sciences, Nankai University, Tiajin 300071, China
Abstract: The equilibrative nucleoside transporters play critical roles in various biochemical and physiological process by regulating the synthesis and transport of nucleosides， such as cell growth， energy metabolism and signal transduction in human being. Meanwhile， the related studies are meaningful for the therapy of cancer and viral infection and other diseases. Here in this review， the recent research progresses of equilibrative nucleoside transporters， including history， classification， molecular structure and mechanism， were summarized and their potential applications in disease treatment and drug development were also discussed.
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