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The Progress on Biological Effect of Muscle-specific MicroRNAs
Han Xiaojie, Yang Shasha, Duan Tingting, Xu Yudong, Wang Yu, Yang Yongqing*, Yin Leimiao*
Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Abstract: miRNAs are a class of small non-coding， single stranded tiny molecule RNA (containing 20-22 nucleotides) that negatively regulates gene expression and translation at post-translational level. They have diverse biological functions and can be used as significant molecule markers for disease diagnosis and prognosis.In this review， muscle-specific miRNAs were introduced， such as the distribution of chromosome， sequence， tissue expression abundance and main pathway of miR-1， miR-133， miR-145 and miR-206. Their biological effects in airway smooth muscle， vascular smooth muscle and cardiac muscle were also discussed.
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