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Deubiquitylase OTUD3 Regulates PTEN Stability and Suppresses Tumorigenesis
Li Hongchang#, Zhang Pengfei#, Yuan Lin, Zhang Lingqiang*
State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Collaborative Innovation Center for Cancer Medicine, Beijing 100850, China
Abstract: PTEN (phosphatase and tension homology， deleted in chromosome 10) is one of the most important tumor suppressors and a small quantity of reduction in PTEN protein level can lead to occurrence and development of tumors. The regulation of PTEN protein stability has been an attractive hotspot. Although several ubiquitin ligases for PTEN have been identified， the deubiquitylase for de-polyubiquitylation and stabilization of PTEN is less defined. We recently report that OTUD3 (OTU domain-containing protein 3) acts as a deubiquitylase for PTEN， de-polyubiquitylates and stabilizes PTEN， then functions as a tumor suppressor in the regulation of breast cancer development. This progress revealed a molecular mechanism that stabilizes PTEN by antagonizing its ubiquitylation.
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