Exercise and Mechanical Load Influence the Bone Metabolism through Bone Morphogenetic Protein

Abstract: There has been bone metabolism in life always. Osteoblast mediated bone formation and osteoclast mediated bone resorption are ever-present， constitute the main parts of bone metabolism. Among numerous growth factors of the bone tissue， BMP is the inducing factor of bone growth， at the same time the bone induction capacity is the strongest. According to the literatures world widely， this review mainly summarises in two parts， the exercise intervention in vivo and mechanical load in vitro. It in detail elaborates exercise and mechanical load by acting on BMP affect bone metabolism condition， and finds that exercise can increase the expression of BMP， promote bone formation， improve bone metabolism. At the same time， the review also emphasizes the relationship between exercise and BMP effect on bone metabolism， and indicates that effective osteogenesis differentiation is highly dependent on the growth factor signals and mechanical load. BMP in mechanical load converts to a biochemical effect of signaling pathway plays an important role in its regulation.

CSTR: 32200.14.cjcb.2016.04.0016