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Biological Function of the Guanine Nucleotide Exchange Factor C3G
Wu Guojin, An Shu, Yang Yang, Liu Ying, Xu Tianrui*, Guo Xiaoxi*
Cell Signaling Lab, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
Abstract: C3G [v-Crk sarcoma virus CT10 oncogene homolog (avian) SH3-domain-binding guanine nucleotide exchange factor] belonging to GEFs (guanine nucleotide exchange factors)， a protein is ubiquitously expressed in various cells. C3G activates small GTPase and is involved in pathways triggered by a variety of signals. It is essential for mammalian embryonic development and many cellular functions in adult tissues. C3G participates in regulating functions that require cytoskeletal remodeling such as adhesion， migration， maintenance of cell junctions， neurite growth and vesicle traffic. In signaling pathways， C3G serves functions dependent on catalytic activity as well as protein interaction and can therefore integrate signals necessary for the execution of more than one cellular function. This article summarizes the most updated knowledge about C3G， and describes the differential expression of C3G in cancer， heart disease and other diseases， providing an overview of the molecular mechanism of its action. Studies of C3G protein interaction will provide important scientific basis for the diagnosis and treatment of ovarian cancer， heart disease and other diseases.
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