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Advance of the Autophagy in Planarian
Kang Jing1,2, Dong Zimei1, Chen Guangwen1*
1College of Life Science, Henan Normal University, Xinxiang 453007, China;
2College of Life Science, Xinxiang Medical University, Xinxiang 453003, China
2College of Life Science, Xinxiang Medical University, Xinxiang 453003, China
Abstract: Planarians are the earliest free-living platyhelminthes with triploblast and bilateral-symmetry，and also the important animal group which transits from water-inhabitation to land. It is required to continuous dynamic adjustment of many processes by the way of proliferation， differentiation， autophagy and apoptosis for maintaining the normal homeostatic balance in planarians. Planarians provide a new in vivo model organism to study autophagy and this makes them very different from other models where autophagy only occurs at very specific times and/or in very specific organs. This review aims to provide a general view of planarians as an autophagy model organism， placing more emphasis on those genes and signaling pathways related to autophagy.
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