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Function and Mechanism of Fever in Regulating Lymphocytes Adhesion and Migration
Lin Changdong, Zhang Youhua, Yang Yanrong, Chen Jianfeng*
State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Fever is a complex physiologic response to bacterial/viral infection and inflammation. Fever is critical for the maintenance of immune homeostasis and immune surveillance by promoting recruitment of lymphocytes into secondary lymphoid organs or inflammatory sites in order to productively encounter foreign antigens. Herein， we review the functions of fever in regulating immune response and its underlying mechanism. We mainly focus on the current understanding on how fever-range thermal stress influences lymphocytes or vascular endothelial cells and finally helps lymphocytes adhesion and extravasation to promote immune responses.
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