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Progress of Autophagy Related to Atherosclerosis
Li Liang, Pei Qianqian, Dong Lihua*
Department of Biochemistry and Molecular Biology, Institute of Basic Medicine, Key Laboratory for Medical Biotechnology of Hebei Province, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang 050017, China
Abstract: Autophagy is a reparative， life-sustaining process to degrade and recycle cytoplasmic contents via the lysosomal system for maintaining cellular homeostasis. Autophagy is involved in the regulation of cell survival and death in atherosclerosis. A moderate amount of autophagy has a protective effect for atherosclerosis，but excessive autophagy can lead to cell death that is not conducive to the stability of the plaque. Therefore，we summarize the progress on the role of autophagy in atherosclerosis， which may provide avenues for further understanding of the mechanism of atherosclerosis.
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