Home > Browse Issues > Vol.38 No.1
The Role of Endoplasmic Reticulum Stress in Insulin Resistance
He Renke, Hu Yuehao, Zhang Jiaping, Fan Qiuju*, Cai Rong*
Department of Biochemistry & Molecular Cell Biology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Abstract: Type 2 diabetes mellitus (T2DM) is increasingly becoming a prominent global health problem.Insulin resistance (IR) plays an important role in promoting the development of T2DM. In recent years， a bunch of studies find that the endoplasmic reticulum stress (ER stress) and IR are inseparable. ER stress acts not only as the direct negative regulatory factor in the insulin signaling pathway， but also targets different tissues in various ways to enhance systemic insulin resistance. In this review， we will give a brief review about the molecular mechanism ofER stress and IR in the occurrence and development of T2DM， as well as the possible targeted therapeutic strategy toward it.
CN
EN