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The Coupling Mechanism of Exocytosis and Endocytosis in the Excitable Cells
Liu Yanmei*, Zheng Xiaolu, Yuan Tianyi, Chen Liangyi*
The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking University, Beijing 100871, China
Abstract: Regulative exocytosis， existing in the excitable cells including neurons， endocrine cells and exocrine cells， is precisely regulated and mediates important physiological activities such as neurotransmitters and hormones release. Following exocytosis， coupled endocytosis occurs within seconds to minutes at spatially correlated sites to retrieve vesicular membrane and proteins on the plasma membrane. The rapid clearance of the vesicle membrane and protein from the exocytic sites will facilitate the next round exocytosis of vesicles at the release sites， balance of surface membrane homeostasis and secretory vesicles recycling. Here we review different modes of exocytosis and endocytosis， and explore the mechanisms of spatiotemporal exo-endocytosis coupling based on the current knowledge and our recent experimental data.
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