Home > Browse Issues > Vol.37 No.11
Role of Autophagy in Cancer Prevention， Development and Therapy
Gao Yuan1, Wang Ying2,3, Huang Zhihui1*
1School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325005, China;
2Ministry of Education, Key Laboratory of Laboratory Medicine, Wenzhou Medical University, Wenzhou 325005, China;
3Research Center of Blood Transfusion Medicine, Zhejiang Provincial People’s Hospital, Hangzhou 325000, China
2Ministry of Education, Key Laboratory of Laboratory Medicine, Wenzhou Medical University, Wenzhou 325005, China;
3Research Center of Blood Transfusion Medicine, Zhejiang Provincial People’s Hospital, Hangzhou 325000, China
Abstract: Autophagy is a process that ensures cellular homoeostasis and qualitycontrol in all mammalian cells. Since the concept of autophagy is put forward， substantial progress has been made in understanding of the molecular signaling mechanism underlying regulation of autophagy. Recently， many studies has focused on the roles of autophagy in cancer and several treatments to cancers by regulating autophagy have been tested in clinical trials. In this study， we give a brief overview of recent findings of the downstream signaling pathways of autophagy，discuss the roles of autophagy in physiological conditions and diseases， and focus on the roles of autophagy in cancer prevention， development and treatment. Meanwhile， we summarize the current clinical trials to treat cancersby regulating autophagy alone or combination with radio-， chemo- or targeted therapy.
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