Home > Browse Issues > Vol.37 No.11
Progress in Studies of Relationship of Hedgehog and the Gastric Gland Differentiation， Correa’s Cascade
Liu Xianyong1, Wang Jianning2*
1Department of Integrated Traditional Chinese and Western Medicine, Jiangning Hospital, Nanjing Medical University, Nanjing 211100, China;
2Department of Gastroenterology, Jiangning Hospital, Nanjing Medical University, Nanjing 211100, China
2Department of Gastroenterology, Jiangning Hospital, Nanjing Medical University, Nanjing 211100, China
Abstract: Hedgehog (Hh) signaling pathway plays a crucial role in a variety of processes， such as embryonic development， gastric gland differentiation， spasmolytic polypeptide-expressing metaplasia (SPEM)，intestinal-type gastric cancer. According to Correa’s cascade of gastric carcinogenesis， gastric cancer was believed to develop from a multistep and sequential process from chronic atrophic gastritis (CAG)， intestinal metaplasia (IM)， dysplasia (DYS) and subsequently to intestinal-type adenocarcinoma. Here， we present an overview of the components and the signal transduction of Hh pathway， the mechanism of Hh signaling pathway in the gastric gland differentiation and the role of Hh pathway in the process of Correa’s cascade of gastric carcinogenesis.
CN
EN