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The Cloning of hDaxx and the Interaction between hDaxx and Pin1
Ming-Liang Chen, Ji-Feng Wang, Ying He, Qin-Xi Li, Zhi-Yun Ye*
Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
Abstract: In this paper we cloned hDaxx gene and showed the evidence that hDaxx interacted and co-localized with the peptidyl-prolyl isomerase Pin1. By using luciferase reporter assay， we found that hDaxx and Pin1 synergically stimulated the transcriptional activity of p53. This founding implicated the Pin1抯 role in the regulation of hDaxx-modulated cell death and provided a potential approach to the understanding of the function of hDaxx.
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