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Wnt Signaling Pathway in Regulating Chondrogenic Differentitation of Stem Cells
Wang Jianyang1,2, Wu Cihu3, Yin Changchang3, Yin Ming1*
1Department of Orthopedics, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China;
2Medicine Graduate School, Nanchang University, Nanchang 330006, China;
3Basic Medical College, Jiujiang University, iujiang 332000, China
2Medicine Graduate School, Nanchang University, Nanchang 330006, China;
3Basic Medical College, Jiujiang University, iujiang 332000, China
Abstract: The Wnt signaling transduction regulates diverse processes such as cell proliferation， regeneration and differentiation. Recent studies have found that Wnt signaling pathway involved in a series stages of decision of differentiation， mesenchymal condensations， chondrogenic differentiation of stem cells and hypertrophy. Its mechanism is important to cartilage repair and cartilage function. This paper reviewed the progress in the canonical and non-canonical Wnt signaling pathway in the regulation of stem cell differentiation into cartilage.
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