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SUMOylation and Its Role in Tumor Development
Zhang Mei1,2, Wang Miao1*, Wu Huijian1*
1School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China; 2Department of Biochemistry and Molecular Biology, Heilongjiang University of Chinese Medicine, Harbin 150040, China
Abstract: SUMOylation is a kind of reversible and highly dynamic post-translational modification of proteins， which could covalently bind SUMO (small ubiquitin-related modifier) to target proteins or remove from target proteins. Currently， four different isoforms， known as SUMO-1， SUMO-2， SUMO-3 and SUMO-4， have been identified in mammals. SUMOylation plays important roles in the regulation of protein functions， such as the stability of proteins， subcellular location， signal transduction and gene transcriptional regulation. Recent studies demonstrate that SUMOylation is closely related to the initiation and the development of tumor. However， the detailed mechanism is still inconclusive. This review will focuse on the possible implications of SUMOylation in the development of tumor.
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