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Advances in HIF-1 and Cardioprotection of Ischemic Myocardial Injury
Ding Ranran1,2#, Ha Yanping1,2#, Wang Zhenliang1,2, Lei Hong1,2, Shen Zhihua3, Guo Junli4*, Jie Wei1,2*
1Department of Pathology, Guangdong Medical University, Zhanjiang 524023, China; 2Pathological Diagnosis and Research Centre, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China; 3Department of Pathophysiology, Guangdong Medical University, Zhanjiang 524023, China; 4Cardiovascular Institute, Hainan Medical College, Haikou 570102, China
Abstract: Hypoxia-inducible factor-1 (HIF-1) is a critical and specific nuclear transcriptional factor， which associates with the pathological phenomena of hypoxia and ischemic injury. HIF-1 plays an important biological role in hypoxic-ischemic diseases through transcription of a series of hypoxia response genes archived with hypoxia response element. Ischemic heart disease is a common clinical fatal etiology， and HIF-1 is tightly associated with the pathophysiology of ischemic heart disease， which plays an important role in protecting the injured myocardium. In this paper， the functional mediation， the regulation of HIF-1 expression in ischemic myocardial injury and the progress in myocardial protection mechanisms are reviewed. Besides， we also prospect the significance of clinical effects of prevention targeted at HIF-1 on ischemic heart disease.
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