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The Change of Paneth Cells in the Toxoplasmosis of Kunming Mice
Zhang Qiongfang, Fu Xiaoying, Wang Kai, Liang Hongde, Yang Yurong*
Animal pathology, College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
Abstract: 1×104 Toxoplasma gondii oocysts were fed to Kunming mice orally. Clinical symptoms and lesions were observed on 1， 3， 5， 6 days after inoculation (DAI). Ileal lesions， the distribution and quantity of T. gondii， the change of paneth cells (PCs) and granules were checked by H&E and immunohistochemical staining. The results showed that the total number of crypts， crypts containing PCs， PCs and granules in ileum were increased first， then decreased explosively， especially in the distal ileum， compared to the control group (P<0.05). The positive area of T. gondii in the ileum was increased. Compared with 1 DAI or 3 DAI， the positive area of T. gondii was the highest at 6 DAI (P<0.05). The results indicated that T. gondii oocysts had a significant influence on PCs of Kunming mice， which providing an experimental basis for the prevention and treatment of toxoplasmosis based on small intestine PCs.
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