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Mechanisms of Iron-sulfur Clusters Assemble in Eukaryotes and Related Diseases
Du Jing, Li Yanchun, Ren Xueying, Tan Guoqiang*, Lü Jianxin*
School of Laboratory Medicine and Life Sciences, Zhejiang Provincial Key Laboratory of Medical Genetics,Wenzhou Medical University, Wenzhou 325035, China
Abstract: Iron-sulfur (Fe-S) cluster is an ancient protein cofactor which has been known with many functions， and it involves in many physiological processes， such as catalysis， electron transport and regulation of gene expression. Despite the simplicity of its structure and composition， Iron-sulfur cluster (ISC) has an complicated assembling process which is a well-organized catalytic reaction. Over the past years the mechanisms of the process of iron-sulfur clusters’ assembly and incorporation into apoproteins have been gradually clarified.Defects in the mitochondrial Iron-sulfur cluster assembly and export systems have a powerful impact on cellular Iron-sulfur protein’s function and intracellular iron distribution. These provided strong evidences for the indispensable role of mitochondrial in life. In this review， we have summarized our current knowledge about the ISC assembly machinery briefly， and presented an overview of various (Fe-S) protein assembly diseases.
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