Home > Browse Issues > Vol.37 No.9
Progress in Regulative Role of Wnt/β-catenin Signaling Pathway in Apoptosis and Necrosis
Zhang Jiamei1,2, Zhao Ning1,2, Wu Xiaoling1,2*, Deng Guangcun1,2*
1Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China,Yinchuan 750021, China;
2School of Life Sciences, Yinchuan 750021, China
2School of Life Sciences, Yinchuan 750021, China
Abstract: Wnt signaling is an evolutionarily highly conserved fundamental signaling system which governs cell proliferation as well as homeostatic processes. It mainly includes three distinct signaling pathways as follows: Wnt/β-catenin pathway， Wnt/Ca2+ pathway and Wnt/planar cell polarity (PCP) pathway. Important roles of Wnt/β-catenin signaling in inflammation and cell fate have been well documented. It has been proved that Wnt/β-catenin signaling pathway plays a dual role in regulating cell fate. It not only inhibits some tumor cell apoptosis by regulating the expression of Survivin， Cyclin and C-myc， but also upregulates the expression of pro-apoptotic protein BIM and Bax， and downregulate anti-apoptotic protein Mcl-1 and Bcl-xl to promote apoptosis. Moreover，the signal pathway can also inhibit the necrosis by inhibiting the excessive secretion of inflammatory factors， and reducing the expression of reactive oxygen species (ROS) and necrosis associated protein PARP-1. In this review，we are narrating the research progress in regulative role of Wnt/β-catenin signaling pathway in cell apoptosis and necrosis.
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