MICOS Complex Is Essential for Regulation of Mitochondrial Membrane Organization

Abstract: Mitochondrion is a dynamic double-membrane-bounded organelle; it is the main site of energy conversion in eukaryotic cell. Mitochondrial cristae are subcompartments of mitochondrial inner membrane. They are arranged orderly and are main sites of ATP production in mitochondria， but the mechanism of cristae formation is poorly known. Recently， MICOS complex was identified to be a key regulator in the cristae formation and morphology， and it played a serious of biological functios in cells. This review will focus on the subunits of MICOS complex， introducing the important functions of MICOS complex and its relationship with human diseases， and giving an overlook of understanding in MICOS complex.

CSTR: 32200.14.cjcb.2015.09.0002