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The Function of F-box Protein Family in Tumorigenesis
Yang Yangyang, Li Shujing*, Wu Huijian*
School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China
Abstract: SCF (Skp1-Cullin1-F-box) complex is a kind of E3 ubiquitin ligase. F-box proteins， one of the subunits that constitute the SCF complexes， mediate the substrate recognition specificity of SCF complex in the ubiquitin-proteasome pathway. Many cell processes， such as cell proliferation， cell-cycle progression，transcription and cell apoptosis， can be regulated by SCF complex through the degradation of specific substrates.The dysregulation of the protein degradation mediated by F-box proteins has been recognized to be closely related to tumorigenesis， so we can design the anticancer drugs targeting F-box proteins. In this review， we summarize the structure characteristics of F-box proteins and try to elucidate the role of F-box proteins in tumorigenesis. This review may provide a new theoretical basis on cilinical treatment of cancer and F-box protein-targeted drug design.
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