Home > Browse Issues > Vol.37 No.8
Advance in Kv7/KCNQ Potassium Channel Openers
Zhang Fan, Qi Jinlong, Liu Yani, Huang Dongyang, Li Li, Zhang Hailin*
Department of Pharmcology, Hebei Medical University, Shijiazhuang 050017, China
Abstract: The voltage-gated Kv7/KCNQ potassium channels are found to be expressed wildly in the central nervous system and play a pivotal role in controlling neuronal excitability. Kv7/KCNQ channel opener become a new tool for clinical intervention of membrane excitability related disorders， such as seizure and pain. Currently nearly thirty kinds of kv7/KCNQ channel openers have been reported. In this paper， we summarized the activation characteristics， activation sites and clinical application of Kv7/KCNQ channel openers.
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