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Human Amniotic Epithelial Cell and Its Immunomodulatory Effects
Si Jiawen1, Shen Guofang1*, Guo Lihe2*
1Department of Oral and Maxillofacial Surgery, Ninth People’s ospital, Shanghai Jiao Tong University School of Medicine,Shanghai 200011, China;
2Institute of Biochemistry and Cell Biology, Shanghai nstitutes for Biological Sciences,Chinese Academy of Sciences, Shanghai 200031, China
2Institute of Biochemistry and Cell Biology, Shanghai nstitutes for Biological Sciences,Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Human amniotic epithelial cells, a special type of stage and tissue specific stem/progenitor cells,have been shown to possess multi-differentiation potential under certain circumstances in vitro and in vivo, and exhibit unique immune privilege characteristics and immunomodulatory effects, which shows the broad research and application prospects of these cells in cell therapy and tissue regeneration fields. With further research progress on the immunomodulatory role of human amniotic epithelial cells, these cells gradually show the potential research and application value in the treatment of immune related diseases. This review focuses on the research progress in biological characteristics and immunomodulatory effects of human amniotic epithelial cells, which may provide references for other relevant studies.