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Research Progress on the Role of Hippo-YAP Pathway in Regulating Various Stem Cells Especially Ovarian Germ Stem Cell Self-renewal
Zhou Fangyue, Li Jia, Pan Zezheng, Liang Xia, Zheng Yuehui*
Department of Experimental Medicine Teaching, Nanchang University, Nanchang 310006, China
Abstract: Stem cell is a kind of self-renewable pluripotent cell. It can constantly self-renewal in stem cell niche， which through its own proliferation division and inhibition of differentiation to increase the number， and remain the pluripotent. YAP， as a oncogene， is the downstream effector of the Hippo pathway. It is a potent transcription coactivator acting via binding to the TEAD transcription factor. YAP is phosphorylated and inhibited by the upstream kinase cascade actions， then the inactivated YAP limits organ overgrowth and inhibits tumorigenesis. Studies have demonstrated that YAP is an efficient growth-inducing agent， which can promote cell proliferation and inhibit differentiation. YAP plays an important role in pluripotent stem cell， neural stem cell， hematopoietic stem cell and epidermal stem cell proliferation and differentiation， and may also regulate the ovarian germline stem cell proliferation and differentiation.
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