Home > Browse Issues > Vol.37 No.7
Physiological Function of Growth Factor Receptor Bound Protein 2 (Grb2)
Zhang Xinyu, An Shu, Guo Xiaoxi, Liu Ying, Yang Yang, Xu Tianrui*
Cell Signaling Laboratory, Faculty of Life Science and Technology, Kunming iversity of Science and Technology, Kunming 650500, China
Abstract: Growth factor receptor bound protein 2 (Grb2) is a ubiquitously expressed adaptor that is essential for a variety of cellular signal transduction pathways and acts as critical downstream intermediary in several oncogenic signaling pathways. The overexpression or aberrant activation of Grb2 is closely related to tumorigenesis. The broad involvement of Grb2 in multisteps of the tumorigenesis makes it an excellent target for antitumor therapy， and plenty of studies have shown that Grb2 molecules can be successfully targeted for antimetastatic therapeutics. Therefore， many Grb2 antagonists have been developed and they show strong antitumor activities. In this article， we summarized the research progress on physiological function of Grb2 and its inhibitors.
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