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Hypoxia-inducible Factor-1 Plays a Dual Role in Brain Injury
Li Yongjin, Yang Kaiyong, Zhang Yi, Chen Yuefang, Huang Xiaojia*
School of Medicine, Jiangsu University, Zhenjiang 212013, China
Abstract: Hypoxia-inducible factor-1 (HIF-1) was found as a regulator factor of high specificity， which was able to perceive oxygen partial pressure of cells and played an important two-way adjustment role in brain injury and its developing process. HIF-1 could increase nerve cell tolerance and facilitate survival in the process of mild and moderate brain injury; when severe injury occured， it could involve in cell apoptosis and facilitate neuronal cell’s death， so it played an important role in brain injury. In-depth study of the HIF-1 and its signaling pathway can provide drug targets in treatment of brain injury and have important theoretical and practical value. Now reviewing on HIF-1 structure， function and regulation of the brain injury is to provide reference for clinical treatment of brain injury.
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