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NAC (Nascent Polypeptide-associated Complex) and Its Alpha Subunit NACA
Liu Jiaoling, Lü Xiaoli, Chen Keping*
Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China
Abstract: NAC (nascent polypeptide-associated complex) is the first cytosolic heterodimeric protein complex to contact nascent polypeptide chains emerging from ribosomes and is evolutionarily conserved in the genomes from archaea， yeast to mammals. NAC is found to be a multifunctional protein which can shield nascent chains， regulate nascent chains translocating into endoplasmic reticulum and mitochondria， repair muscle damage and so on. However， its α subunit NACA/αNAC (nascent polypeptide-associated complex alpha subunit) is identified mainly functioning in transcriptional regulation. It may play a role in FADD-mediated signal transduction process. Moreover， in many viral diseases， such as the Viral Hepatitis Type B， C and the African swine fever， it is found to be able to interact with the relevant viral protein to cause physiological disorders. Even in the brain tissues of patients with Alzheimer’s disease and Down syndrome， NACA is found downregulated.
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