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MicroRNAs and Its Functional Regulation on Calcium Handling of Cardiac Sarcoplasmic Reticulum
Cui Yurong, Yin Mengmeng, Sun Xiaoxi, Hong Xian, Luo Xueying, Zhong Binlong, Xi Jiaoya*
Department of Physiology and Institute for Brain Research, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, the Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan 430030, China
Abstract: The properties of sarcoplasmic reticulum (SR) calcium handling are crucial for differentiation， development and maturation of cardiomyocytes， and are also the basic for cardiac contraction and heart pumping. Lots of heart diseases are related to the dysfunction of SR calcium handling. Accumulated data were amassed showing that microRNAs (miRNAs) participated and played important role in regulating cardiac SR calcium handling， and contributed to some heart diseases or protection of heart function. Here we aimed to review the recent progress on miRNAs regulating calcium handling of cardiac SR and their underling mechanism， and provide a future perspective for the application of miRNAs studies on the clinical diagnosis and treatment of cardiac diseases.
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