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The Structure and Function of SCF and APC/C
Lin-Hai Shen, Jia-Ping Chen1, Li-Hong Xu*
Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058, China
Abstract: The cyclin-dependent kinases (CDKs) is a driving force of the cell cycle， and the activities of CDKs are controlled by the ubiquitin-proteasome pathway (UPP) through proteolysis of key regulators such as cyclins and CDK inhibitors. Two ubiquitin ligases， the Skp1-Cul1-F-box protein (SCF) complex and the anaphase-promoting complex/cyclosome (APC/C)， are responsible for the specific ubiquitylation of many regulators in cell cycle. Deregulation of the proteolytic system might result in uncontrolled proliferation， genomic instability and cancer. In this review， the structures of these two ubiquitin ligases and their functions in mechanisms of cell cycle control and cancer were summarized.
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