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Progress on the Mechanism of Intracellular Degradation of β-Amyloid Protein
Zheng Bangxu, An Pengyuan, Jiang Liting, Zheng Yiyi, Wang Qinwen, Xu Shujun*
School of Medicine, Ningbo University, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China
Abstract: Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in elderly people. β-amyloid protein (Aβ) is considered to be the most important pathogenic factor affecting the process of AD. There is a balance between production and degradation of Aβ in brain. Besides the increased production of Aβ， the decreased degradation also plays an important role in the process of AD. Lysosome is the main organelle for intracellular
Aβ degradation. Recent studies found that lysosome modulators could prevent the impairment of learning and memory induced by Aβ. These findings suggest a serious role of lysosome in the intracellular degradation of Aβ. Our goal is to understand the mechanism of Aβ degradation mediated by lysosome， and the related mechanisms of Aβ uptake and transportation.
Aβ degradation. Recent studies found that lysosome modulators could prevent the impairment of learning and memory induced by Aβ. These findings suggest a serious role of lysosome in the intracellular degradation of Aβ. Our goal is to understand the mechanism of Aβ degradation mediated by lysosome， and the related mechanisms of Aβ uptake and transportation.
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