Home > Browse Issues > Vol.37 No.5
Advances in Cell Sources for the Treatment of End Stage Liver Disease
Sun Xiao, Yu Bing, Chen Fei, Wang Minjun, He Zhiying, Hu Yiping*
Department of Cell Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China
Abstract: Liver diseases caused by different factors can develop into end stage liver disease. Currently， orthotopic liver transplantation is considered to be the only effective treatment for end stage liver disease. However， it has been restricted by shortage of donor liver， immune rejection and other reasons. Cell therapy has emerged in recent decades as an alternative option for end stage liver disease. Especially， the lineage reprogramming technology， which was used to induce hepatic stem cells and hepatocyte-like cells， not only offers a new strategy to solve the shortage of liver cells， but also accelerates clinical transitional process of cell therapy. This review introduces the present situation on source of cells for liver disease treatment， and highlights the progress of hepatic cells obtained from lineage reprogramming.
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