Home > Browse Issues > Vol.37 No.5
The Progress of Embryonic Angiogenesis
Gao Cheng1, Yan Xiaoyi1, Zhuo Wei1, Zhu Biao2, Zhou Tianhua1*
1Department of Cell Biology, School of Basic Medical Sciences, Zhejiang University, Hangzhou 310058, China; 2Zhejiang Provincial People’s Hospital, Hangzhou 310024, China
Abstract: Cardiovascular system is essential for the transport of oxygen and nutrients to tissues. Therefore， cardiovascular system is the first organ to develop and reach a functional state during embryogenesis. Blood vessel formation initiates during gastrulation， wherein mesoderm cells differentiate into endothelial cells by the inducing signals from the endoderm. Angiogenesis is a critical event for the formation of the vascular network， which contains two models: sprouting angiogenesis and intussusceptive angiogenesis. Sprouting seems to be the most extensive mechanism， which undergoes the following progression: the destruction of the basement membrane， the migration and proliferation of endothelial cells， lumen formation， vessel maturation and stabilization. This paper reviews the progress of embryonic angiogenesis in recent years from three aspects: the origin of endothelial cells， the process of angiogenesis and the regulation of angiogenesis.
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