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TOR Signaling Pathway in Yeast
Ling-Huo Jiang*, Zhi-Hui Yan
College of Pharmaceuticals and Technology, Tianjin University, Tianjin 300072, China
Abstract: Target of rapamycin (TOR)， a member of the phosphatidylinositol kinase-related protein kinase (PIKK) family， is highly conserved in eukaryotes and regulates growth and proliferation of yeast， fly and mammalian cells. TOR promotes the phosphorylation of its downstream targets， leading to increased protein synthesis and decreased protein turnover， and therefore controls transcription and translation of nutrient-regulated genes in response to environmental changes of nitrogen or carbon sources. This review summarizes recent advances in studies on the TOR signaling in budding yeast.
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