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Imbalance of DNA Repair Caused by Breast Cancer Specific Copy Number Variation
Gao Meng1, Cheng Zhujun2, Zhang Cheng1, Xiong Zhaoping2, Liao Weiting2, Deng Libin1,2, Lu Quqin1*
1School of Medicine, Nanchang University, Nanchang 330006, China; 2Institute of Translational Medicine, Nanchang University, Nanchang 330006, China
Abstract: We integrated 56 pathways related to DNA repair from databases (KEGG， GO， WIKI and PC)， and identified 725 DNA repair genes. Based on the genomic data from CCLE and TCGA， we detected four candidates related to DNA repair (BRCA1， ERBB2， G6PC and PSME3) from 89 genes mapped to the copy number variation (CNV) restricted in breast cancer. Further interpretation revealed that the CNV of 17q21.31 could affect the DNA repair (such as “double strand breaks repair” and “DNA damage related detection point”) by changing the expression of BRCA1 and PSME3 in breast cancer.
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