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The Retrograde Transport of Ricin around / in Endoplasmic Reticulum
Qiong Liu, Jin-Biao Zhan1*
Institute of Biochemistry and Cell Biology, Ningbo University Medical School, Ningbo 315211, China; 1Department of Biochemistry and Genetics, Zhejiang University Medical School, Hangzhou 310058, China
Abstract: Ricin is a plant-derived ribosome inactivating protein. To target ribosomes in the mammalian cytosol， ricin must firstly retrograde transport to the endomembrane system of the cell to reach the endoplasmic reticulum. Here， the toxin is reduced and the catalytic A chain is recognised by endoplasmic reticulum components that facilitate its membrane translocation to the cytosol. This review summarises current understanding of these events.
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