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Function of NLRP3 Inflammasome in Influenza Virus Infection
Niu Junling1,2,3, Chen Mingkuan2, Wu Shuxian2, Meng Guangxun2, Xu Cunshuan1,3*, Lu Ailing2*
1College of Life Science, Henan Normal University, Xinxiang 453007, China; 2Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China; 3State Key Cultivation Base for Cell Differentiation Regulation, Xinxiang 453007, China
Abstract: Abstract NLRP3 (NOD-， LRR， and pyrin domain-containing 3) inflammasome is activated by a diversity of conserved motifs from pathogens and endogenous danger signals， which results in Caspase-1 activation and triggers the maturation and secretion of pro-inflammatory cytokines such as Pro-IL-1β and Pro-IL-18 to engage immune defenses. This is an important immune mechanism in fighting microbial infections. In this review， we discussed the structure and mutation of influenza virus， cellular recognition of this virus， activation of the NLRP3 inflammasome by influenza virus， function of NLRP3 in combating influenza virus infection， as well as viral evasion from host immune responses.
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