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Advance in Structure and Protein Function of RECQL5 Gene
Wan Liangqin1, Li Weihong1*, Liu Yaming2, Li Fanghe1, Zang Yanyan1, Zhang Sai1, Jiang Zhaoyan1, Ma Jiabao1, Hu Yanhong1
1Beijing University of Chinese Medicine, Beijing 100029, China;
2Beijing University of Aeronautics & Astronautics, Beijing 100191, China
Abstract: RECQL5 (RecQ protein-like 5) is one of members of the RecQ family of DNA helicases， and belongs to the DEXH-box DNA/RNA helicase family. The mutation of WRN， BLM and RECQL4 genes in RecQ family could lead to some genetic diseases. However， it has not yet be found that RECQL5 gene is associated with any human disease. The recent research has shown that RECQL5 plays a very important role in keeping the stability of DNA， regulating the replication， repair， recombination and transcription of DNA. Herein， the structure and biochemical characteristics of RECQL5 gene were reviewed.
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