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Autophagy and Its Role in Tumor Development
Ye Jun, Wang Hui, Huang Xuemei, Guo Jianquan, Yang Huanjie*
School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China
Abstract: Autophagy is a conserved process of protein degradation with characteristic of autophagosome formation followed by fusion with lysosome. Autophagy is composed of four basic steps， the initiation， autophagosome formation， maturation and lysosome reformation， all of which are controlled by autophagy related proteins. In addition， autophagy is regulated by mTOR， PI3K， ULK1 and transcription factors as well as microRNAs. Autophagy plays a key role in the maintenance of the homeostasis in cells， and also has a complex impact on tumor initiation and development.
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