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Independent and Interactive Effects of Transcription Factor CREB and Its Related miRNAs in Tumorigenesis
Meng Xiangyu, Zhuang Haihui, Wang Xue, Wang Ping*
Department of Human Anatomy, Histology and Embryology, the Center for Translational Medicine, Ningbo University School of Medicine, Ningbo 315211, China
Abstract: Cyclic AMP responsive element-binding protein (CREB) is a proto-oncogenic transcription factor， and generally affects the tumorgenesis by regulating the expression of targeted genes. Recent reports showed that the mechanism of miRNAs， as proto-oncogenes or suppressor genes in tumorigenesis， was tightly related with CREB. Combined with present research， this review summarized the independent and interactive effects of transcription factor CREB and its related miRNAs in tumorigenesis.
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