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The Research Progress of Gene-Recombined-Mesenchymal Stem Cells Therapy in Gastrointestinal Cancer
Peng Yao1,2, Zhong Muxiao1,2, Yang Gongli2,3, Zhang Yali1,2*
1Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 2Guangdong Provincial Key Laboratory of Gastroenterology, Guangzhou 510515, China; 3Department of Gastroenterology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
Abstract: Mesenchymal stem cells (MSCs) are a group of non-hematopoietic progenitor cells mainly derived from bone marrow and other stromal-tissues. Recently， they have been attracting extensive attention of researchers as a new kind of vehicles for gene therapy. Studies have shown that they have the properties of migrating towards tumors， regulating the immune system and low immunogenicity， and providing them as suitable and efficient vehicles to deliver therapeutic gene to tumor. Here， we reviewed the researches of MSCs-based gene therapy in gastrointestinal cancer and proposed the existing challenges and concerns therein.
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