Home > Browse Issues > Vol.37 No.3
Mechanisms Underlying Integrin Deactivation
Lu Ling, Zhang Youhua, Lin Changdong, Chen Jianfeng*
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Abstract Integrins are a family of α/β heterodimeric cell adhesion molecules， playing key roles in a number of important biological processes， such as immune responses， leukocyte trafficking， maintenance of tissue homeostasis and development. The function of integrins is dependent on the dynamic regulation of integrin affinity and its intracellular signaling. The abnormal integrin activation and deactivation are associated with many human diseases. Studies have revealed that the binding of intracellular proteins， such as talin and kindlin， to integrin cytoplasmic tail is a critical step for integrin activation. However， less is known about the mechanism of integrin deactivation. In this review， we aim to discuss the recent progresses in understanding the mechanisms underlying the integrin deactivation.
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