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Regulation Mechanism of Bone Marrow Niche on Hematopoietic Stem Cell Quiescence
Li Huan, Rao Qing*
State Key Laboratory of Experimental Hematology, Institute of Hematology, Blood Disease Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
Abstract: Hematopoietic stem cell (HSC) is characterized by its potentiality in self-renewal， multipotential differentiation and quiescence. Quiescent state is more important to maintain the number of HSC and the stability of HSC pool. HSC resides in bone marrow niche， which provides necessary soil to maintain HSC quiescence. Bone marrow niche， especially osteoblast niche， regulates HSC quiescence through a variety of transmembrane molecules， signaling pathways and adhesion molecules. Quiescence of HSC is critical for HSC’ self-renewal. Imbalance between self-renewal and quiescence may be associated with leukemogenesis and even be essential for leukemia stem cells’ stemness. In this review， based on the recent research progress and the results of our study， we briefly reviewed the current advances of the quiescence regulators in the bone marrow niche for the HSC.
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