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The Actuality of Filaggrin Gene and Filaggrin
Liu Xiaofeng, Wu Yan*
Department of Histology and Embryology, School of Basic Medicine Science, Inner Mongonlia Medical University,Hohhot 010110, China
Abstract: Filaggrin gene (FLG)， located at human chromosome 1q21.3， is closely related to cell differentiation. FLG can translate to Profilaggrin. Profilaggrin is degraded by Kallikrein5 (KLK5) to Filaggrin， which is correlated with the integrity of epidermal barrier. Filaggrin is broken down by Caspase-14 into small molecular substances， which can play the role of waterproof and ultraviolet rays (UV) protection. Mutation or deficiency of FLG results in decreasing production of Filaggrin， which is the basic causes of some diseases. This article focuses on reviewing the regulation of FLG and the relationship between Filaggrin and related diseases.
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