Home > Browse Issues > Vol.29 No.3
Establishment and Improvement of Primary Hepatocarcinoma ICR Mouse Model by Injection Method
Yu Zhang1, Han-Wen Xu1, Tai-Ping Zhang, He-Yun Zhang*
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
Abstract: Primary hepatocarcinoma ICR mouse model was successfully established with improved injection method. The model mice were analyzed by weight survey， success ratio of primary transplant and pathological analysis. Results demonstrated that the improved method increased the success ratio greatly， simulated multiple-organ metastasis and common symptoms of human liver cancer well. The model can satisfy the needs from exploitations of anti-cancer drugs and researches on cancer mechanism. In addition， the protocol and idea in the method not only solved the technical difficulty of injection method caused by tumor cells leaking but also laid the foundation for establishment of other primary and secondary cancer models.
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