MicroRNA Regulates Adipogenesis in Mammalian

Abstract: The differentiation of adipocyte-derived from mesenchymal stem cells or preadipocytes into mature adipocytes is essential for fat formation and metabolism of adipose tissues in mammals. It is regulated by hormones and various adipogenic transcription factors which are expressed as a transcriptional cascade to promote adipocyte differentiation， leading to the mature adipocyte phenotype. Recent findings indicated that microRNA (miRNA)， a family of small RNA molecules of approximately 22 nucleotides in length， were involved in the regulatory network of many biological processes， including cell differentiation， through post-transcriptional regulation of transcriptio n factors and/or other genes. This review summarizes the recent progress about adipogenesis regulation of miRNAs with the proadipogenic or antiadipogenic factors manner in mouse， human and cattle. It may provide a useful reference for researcher’s working in this field.

CSTR: 32200.14.cjcb.2015.01.0016