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The Role of Chemokine CXCL1 in Tumor Progress
Ye Liying1, Ye Jun2*
1Fujian Health College, Fuzhou 350101, China;
2Life Science College of Xiamen University, Xiamen 361102, China)
Abstract: Chemokines and their receptors play an important role in many biological processes such as inflammation and angiogenesis. Chemokine CXCL1 is a monomeric protein of chemotaxis cytokines. It usually binds to G protein coupled receptor CXCR2 specifically， and has effects on tumor growth， proliferation， metastasis， invasion and angiogenesis in various cancers. This paper mainly focuses on the role of a subfamily member of chemokine CXCs， CXCL1 in tumors， and of upstream regulatory factors on its expression， in order to explore the relationship between CXCL1 and tumor progress.
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