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Research Progress of Epithelial-Mesenchymal Transition in Malignant Melanoma
Song Dengyan, Song Xin*
Cancer Biotherapy Center, Yunnan Cancer Hospital, the Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China
Abstract: Malignant melanoma (MM) is the most aggressive skin cancer， which is deadliest once metastasized. Epithelial-mesenchymal transition (EMT) plays an important role in the process of invasion， metastasis， drug resistance and immunosuppression in MM. Some related factors such as E-cadherin， N-cadherin， Twist， Snail， Slug， Zeb-1， Zeb-2， vimentin and microRNAs associate with the EMT. Here we reviewed recent studies that aimed to better understand the role of EMT in the process of MM， and discussed opportunities for novel approaches for MM therapy.
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